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The possible synergistic effect of CQ and TRAIL was evaluated using the isobologram method.

T-cell response, this effect can probably be explained by the chloroquine-mediated rescue of OVA protein from the endocytic degradation that occurs in maturing DCs, as well as facilitating export of the antigen to the cytosol for proteasome-dependent processing ().

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For drug treatment, cells were incubated with or without 10 or 20 μ M roscovitine (Merck, Darmstadt, Germany), 2 mM hydroxyurea, 10, 50 or 100 μ M chloroquine, or 10 μ M Chk2 Inhibitor II (Sigma, St.

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Although there is currently no evidence for enhanced gametocyte production in HIV-infected individuals, these associations indicate the occurrence of more-frequent, longer, and higher-density asexual parasite carriage in HIV-infected individuals.

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Therefore, we analyzed whether co-treatment with CQ and TRAIL stimulates caspase-3 (DEVDase) activity.

These resistant strains spread rapidly, producing a large mortality increase, particularly in Africa during the 1990s.

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In Zambia, many children suffering from malaria did not receive the appropriate 3-day course of chloroquine because their caregivers did not receive adequate instruction on how to administer the drug (Baume et al.

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In this study, treatment failure occurred in only 1 child among 105 participants assigned to receive chloroquine for uncomplicated falciparum malaria.

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Earlier evidence had suggested that chloroquine-resistant parasites may have a survival advantage.

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